Oncology

Radiation Oncology

Radiotherapy is a major curative treatment modality and an integral part of cancer treatment. Nearly 60-70% of all cancer patients will require radiotherapy as a part of their treatment.

Facilities

The specialists follow accepted standard guidelines in treating cancer patients as follows:

• State-of-the-art Varian TrueBeam HyperArc with SGRT Linear Accelerator for advanced external radiation treatments.
• multichannel Nucletron microSelectron HDR brachytherapy for internal radiotherapy
• Dedicated CT simulator.
• The department utilizes latest & advanced radiotherapy techniques like RapidArc, IGRT/IMRT, SRS/SBRT, 3DCRT, Image guided brachytherapy which dramatically increases the safety of radiotherapy, reduces the side effects and improves control rates.

Medical Physics, an integral part of the department of Radiation Oncology comprises of a Chief Physicist / RSO and three Medical Physicists. Their primary work includes advanced radiation treatment planning for cancer patients, maintenance, quality assurance, commissioning and decommissioning of radiation equipments.

Surgical Oncology

Surgical Oncology Department has team of experienced and qualified Surgical Oncologists for the management of cancer patients.

Their services are backed by skilled anaesthesiologists and post operative nursing care. Surgical oncology offers surgical procedures with least morbidity.

Following are few of them:

• Sub total esophagectomy with two field dissection. Performed 250 cases so far.
• Sphincter preserving rectal cancer surgery (Low / Ultra low anterior resection)
• Breast conservation surgery with sentinel node biopsy to avoid lymphedma (swelling of upper limbs).
• Minimal invasive procedures for colo-rectal and uterine cancer.
• Laryngectomy and laryngo tracheal resections.
• Major oral resections and reconstruction with micro vascular flap.
• Major thyroid surgeries with tracheal reconstruction.
• Genito urinary surgeries like radical / partial nephrectomy for kidney cancer, radical cystectomy with neo bladder reconstruction for urinary bladder cancer.
• Limb salvage surgeries for soft tissue and bone sarcomas.
• Penile cancer surgery with sentinel node dissection for Inguinal Nodes.
• Staging laparatomy for cancer of uterus (Endometrium) and ovaries.
• Wertheim's hysterectomy for carcinoma cervix

Haematology

Facilities

• 8 bedded low count ward for management of neutropenic patients.
• Stem cell unit includes a separate apheresis unit for collection of stem cell, stem cell storage with cryopreservation facility.
• Unit includes 4 fully functional HEPA filtered beds.
• We also offer Chemotherapy Day Care facility, comprehensive services for diagnosis and treatment of anaemia and other benign blood disorders.

The Division of Haematology treats people with blood disorders.

Following are few of them:

• Adult and pediatric malignant and benign haematological disorders

1. blood cancer including Acute leukemias, Multiple myeloma, CML, CLL, lymphomas etc, histiocytic disorders including LCH, HLH etc,
2. anemia including hemoglobinopathies like thalassemia, sickle cell disease,
3. bleeding disorders including congenital coagulation and platelet function disorders,
4. thrombotic disorder like DVT, PTE evaluation and management and
5. Primary immunodeficiency disorders including SCID, CVID and others.
6. BONE MARROW STUDIES
7. INTRA THECAL PROCEDURES
8. CENTRAL LINE, PICC LINE AND HICKMANN CATHETERS

• Stem cell transplant treatment for leukemias, lymphomas, Myeloma, hemoglobinopathies and Primary immunodeficiency disorders.
• Stem cell transplant center performs autologous and allogeneic stem cell treatment including half match (Haplo) transplant which only very few centers around the country has performed.

Cancer Runs in Families Too - GKNM's Cancer Genetics Clinic Can Help

When cancer strikes a family, it often brings not only medical challenges but also fear, uncertainty, and questions about the future. "Will this affect my children?" "Am I at risk too?" These are concerns many families silently carry.

While most cancers happen by chance, about 5-10% are hereditary. This means an altered gene, passed from parent to child, increases the risk of certain cancers. In such families, cancers may occur at a younger age or affect more than one member.

The Cancer Genetics Clinic at GKNM Hospital, Coimbatore, was set up to help families find answers. The clinic offers genetic testing, a simple but powerful tool that can show whether someone carries a cancer-related gene mutation. More importantly, it provides guidance and support -from regular check-ups and early screening to preventive strategies that safeguard both the individual and their loved ones.

You may benefit from genetic testing if:

• Cancer was diagnosed at a young age (under 50 years).
• Two or more close relatives have the same or related cancers.
• A person has had two different primary cancers.
• A family member has had a rare cancer linked to inherited syndromes.
• A known genetic mutation has already been identified in the family.

Why this matters

Knowing your risk is not about living in fear-it's about living with confidence. Genetic testing can give families clarity, protect children and future generations, and allow doctors to detect cancers earlier, when treatment works best.

Clinical Research & Trial

V N CANCER CENTER started its clinical research services in 2008. We provide clinical research services for pharmaceutical and biotechnology product development from Phase I to Phase IV. G.Kuppuswamy Naidu Memorial Hospital has an efficient Pl group Specialities in major therapeutic areas like Oncology, Cardiology and Endocrinology.

Investigator Initiated Trials

Medical Oncology

A Prospective, Multicenter, Observational Study Examining The clinical Utility Of Canscript in Routine Clinical Practice" - Dr.A.Rajkumar

Agency Sponsored Trials

Medical Oncology

Aspirin for Dukes C and High Risk Dukes B colorectal cancers-An international, Multi centre, Double blind, Randomized Placebo Controlled Phase III Trial - INDOX, Dr.B.Sivanesan

Radiation Oncology

• Resource sparing curative treatment for Rectal Cancer - IAEA, Dr. M. Nagarajan
• A randomized multicenter trial of accelerated hypo-vs. normo-fractionated radiotherapy for head and neck squamous cell carcinoma (IAEA-HYPNO trial) - IAEA, M. Nagarajan
• Role of Human Papillomavirus Infection and other co-factors in the Aetiology of Head and Neck cancer India and Europe -WHO/IARC/ICMR, M. Nagarajan

Company Sponsored Trials

Medical Oncology

• Prospective, multi-centre, randomized, open-label, two-arm, parallel group, active control, comparative clinical study to evaluate efficacy, safety and pharmacokinetics of XXXXX/ Avastin™ when given intravenously in patients with Metastatic colorectal cancer Dr. B. Sivanesan
• A Multi-center, randomized, double-blind, vehicle-controlled, phase-2 trial to evaluate the efficacy and safety of two concentrations of topical povidone-iodine nail solution (VBP-926) for the treatment of chemotherapy-associated paronychia in cancer patient - Dr. B. Sivanesan
• A Phase II/III Pivotal, Open-label, Randomized, 3Arm Study to Assess the Efficacy of LNP3794 Monotherapy or in Combination with Docetaxel, Compared with Docetaxel Alone, in Patients with RAS Mutation Positive Locally Advanced and Metastatic Non-Small Cell Lung Cancer - Dr. B. Sivanesan
• Prospective, multi-centre, randomized, open-label, two arm, parallel group, active-control, comparative clinical study to evaluate efficacy, safety and pharmacokinetics of XXXX/ Herceptin (HerclonTM) when given intravenously in patients with Metastatic HER2-Over expressing Breast Cancer - Dr. A. Rajkumar

Radiation Oncology

A Phase III, open-label, Randomized, Multi-center study of the effects of Leukocyte Interleukin, injection[xxxxxx} plus standard of care (Surgery + Radiotherapy or Surgery+Concurrent Chemoradiotherapy) in subjects with Advanced primary Squamous Cell Carcinoma of the oral cavity/Soft palate versus standard of care only - CEL SCI, Dr. M. Nagarajan

Heamato Oncology

• Observational Follow up for patient who has received BCD-020 (rituximab, CJSC BIOCAD, Russia) / Mabthera for CD20-positive indolent non-Hodgkin lymphoma in BIORIX study -Dr. B. Sivanesan
• A Phase 3 Randomized, Controlled, Open-Label Study of Selinexor, Bortezomib, and Dexamethasone (SVD) versus Bortezomib and Dexamethasone (Vd) in Patients with Relapsed or Refractory Multiple Myeloma (RRMM) - Dr. B. Sivanesan
• SADAL: A Phase 2b Open-label Study of Selinexor (KPT-330) in Patients with Relapsed/ Refractory Diffuse Large B-Cell Lymphoma (DLBCL) - Dr. B. Sivanesan