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Heart Valve Disease -  Heart Valves
The heart consists of 4 chambers. The two upper chambers are called artium and the two lower chambers are called the ventricles. The two artia are separated by a wall called artial septum into right artium and left artium. The two ventricle are separated by another wall called ventricular septum into right ventricle and left ventricle. The right and left sides of the heart are completely separated normally with no communication.
The heart contains 4 valves, which open to allow blood to more forward and closes to prevent any backward flow.

  • The Mitral valve allows blood to move from left atrium into left ventricle
  • The Aortic valve allows blood to move out of left ventricle into aorta
  • The Tricuspid valve allows blood to move from the right atrium into right ventricle
  • The Pulmonary valve allows blood to move from right ventricle into Pulmonary artery
Valve disease
Heart valves can be abnormal from birth or damaged by Rheumatic fever, bacterial infection and calcific degeneration. Valves also degenerate with normal aging. Valve abnormality can result in

Stenosis
- where the opening becomes narrow
Regurgitation
- where the valve does not close properly leading to back flow of blood
Mixed -both exists.
 Common symptoms of valve disease include
  • Shortness of breath
  • Chest pain
  • Fatigue
  • Swelling of legs and ankles
  • Dizziness/fainting
  • Palpitations
Valve diseases left untreated will lead to
  • Cardiac failure
  • Strokes
  • Irregular heart rhythm
  • Finally death

Diagnosis

 Is based on medical history, physical exam, and tests which include a Chest X-ray, ECG and Echocardiogram. Echocardiogram is usually the confirmatory test. Occasionally one may need an angiography to confirm valve leaks and to rule out associated coronary disease especially if the patient is a male above 45 yrs or a female above 50 yrs

Treatment


Valve diseases can be treated medically in initial stages but most of them will need intervention in due course. The modalities available are

Balloon valvotomy
Best suited for pure mitral stenosis (suitability assessed by Echo) and pulmonary valvar stenosis. Limited role in aortic stenosis. Performed by Cardiologists, a non-surgical method.


   Valve repair
The current trend is to preserve the natural valve when possible. There are various techniques of repair. This is very successful in mitral and tricuspid valves and less so in aortic valves. Rings are used to support the valves called annuloplasty rings. The major advantage is to avoid anticoagulation. Our center has done more than
100 repairs with very good success.

  Valve Replacement

When the natural valve is damaged and beyond repair it has to be replaced. The surgeon excises the valve and substitutes it with a prosthesis.



Valve substitutes
Valve prosthesis are of 2 basic types


Mechanical valves

Most commonly used. Various types available, Ball and Cage (Starr-Edwards), Monoleaflet (Medtronic) and Bileaflet( St.Jude's). Most of them are made of graphite coated with carbon by a process called pyrolysis which render it very strong.

Mechanical valves last usually for a life time but has the disadvantage of being thrombogenic (promote clots). In order to avoid this patients with mechanical valves have to be on life long anticoagulation



TTK-Chitra Valve
This is mono leaflet tilting disc valve made in India. Developed by the Sree Chitra Institute in Trivandrum and presently manufactured and marketed by TTK limited. Our centre was one of the five National centers which participated in the trial of this valve initially.

The disc of this Valve is made of polyethylene and is less noisy than other valves. the greatest advantage is the cost. It cost 50% of its foreign counterparts. it is available in all standard sizes and is easy to implant. we have one of the largest series in this country with excellent follow-up. The results are very good. so far our centre has implanted 281 valves since 1992.

Bilogical or Tissue valves
These are valves prepared from animals usually pig or cow. They are mounted on frame called stent and treated to prevent rejection. Currently valves without stents called Stentless valves are also available which are supposed to perform better.
The major advantage of tissue valves is the no need for anticoagulation but the limitation is the longivity. They degenerate and fail between 8-15 yrs. Younger the age earlier the failure.






The best available tissue substitute is the Homograft (human valve) which is harvested from cadavers, treated and cryo preserved. It is limited by availability and cost.

How to choose a valve?
Difficult decision indeed. Patients should be explained about the advantages and disadvantages of both types. Selection is basically "Anticoagulation vs Durability". The current guideline is:-
  • Mechanical valve in patients < 60 years.
  • Tissue valves in patients > 65 years
  • Tissue valves in patients whose life expectancy is < 10 years
  • Tissue valve in patients who have problems which are likely to cause life
    threatening bleeding.

Special situation :

Patients 60-65 years -decision should be based on consultation with patient

Females in reproductive age group. The option of implanting a tissue valve is idealas it avoids the risk of damage to the foetus due to anticoagulant drugs. This has to be discussed with patient as they would definitely need are-replacement of the valve in 8-10 years time.

Patients who want to pursue adventure sports -The option of a tissue valve is better as anticoagulation would pose increased risk of bleeding in an injury situation.

 Is re-operation risky?
Any re-operation in the heart poses additional risk due to difficulty in re-entry. The heart will be stuck to the pericardium and anatomical planes will not be preserved. But in the present day the increased risk still exists but is very small, due to better techniques and expertise.


 Anticoagulation
:

 Patients receiving a mechanical heart valve require a blood thinner (Warfarin, Acitrom) to prevent clots. Other associated conditions like irregular heart beat (atrial fibrillation) and enlarged heart may also be treated with warfarin. Some surgeons also prefer to put their patients with biological valves also on a small dose of warfarin for 6-12 weeks.

Warfarin works by prolonging the time for the blood to clot. The drug must be carefully monitored by doing a blood test called INR. INR should be done once a month ideally. WHO recommends that the INR should be between 2.5 to 3.5 for patients with prosthetic mechanical valves. Too high a level will cause bleeding problem and too Iow a level will cause embolism. To keep the levels steady it is advisable to take this drug at a specific time each day. We advice 6 pm. every day. One should avoid heavy alcohol consumption, certain types of food (high in vit-K) and some medicines. Please check with your doctor before taking any over the counter medications including cold remedies, antibiotics, vitamins and sleeping pills.

Patients on warfarin should report to the doctor if they experience bleeding from gums, nose bleeds, blood in urine or stool, spotting of blood while coughing or excessive menstrual loss. Also report immediately to the doctor if they experience a transient loss of consciousness, weakness of a limb or blurring of vision.

 Other Procedures

Patient should inform any physician, surgeon or dentist that he is on warfarin. The drug should be stopped two days prior to any procedure including dental extraction. The INR should be checked on the day of procedure and it should read < 1.4. Warfarin is to be resumed on the evening of procedure. If the patient cannot take the drug orally, Heparin should be started.


 Pregnancy


All oral anticoagulants are teratogenic (can cause deformities in the fetus). The risk is maximal in the first trimester. It is ideal to switch to Heparin in the first trimester if pregnancy is planned. Currently we do not recommend switching to heparin if pregnancy is detected after few weeks of exposure to the drug as the benefits are not overwhelming.


 Endocarditis prophylaxis


 Endocarditis is a serious life threatening infection of the heart. Patients with valve diseases and prosthetic valves are at increased risk. All these patients need antibiotic coverage to prevent infection before any procedure including dental extraction. Always consult your doctor before any dental or surgical procedure.



Rheumatic Prophylaxis

All patients with rheumatic heart disease are advised to have Prophylaxis against further attacks. This is achieved by taking a long acting penicillin (Penidure) injection once every 3 weeks. Currently it is advised to have this prophylaxis life long.


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